General Information

  • ID:  hor001613
  • Uniprot ID:  P42564
  • Protein name:  FMRFamide-like neuropeptide GGKYMRF-amide
  • Gene name:  NA
  • Organism:  Hirudo medicinalis (Medicinal leech)
  • Family:  FARP (FMRFamide related peptide) family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Hirudo (genus), Hirudinidae (family), Hirudiniformes (suborder), Hirudinida (order), Hirudinea (subclass), Clitellata (class), Annelida (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  GGKYMRF
  • Length:  7(1-7)
  • Propeptide:  GGKYMRF
  • Signal peptide:  NA
  • Modification:  T7 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor001613_AF2.pdbhor001613_ESM.pdb

Physical Information

Mass: 96522 Formula: C39H59N11O9S
Absent amino acids: ACDEHILNPQSTVW Common amino acids: G
pI: 10.45 Basic residues: 2
Polar residues: 3 Hydrophobic residues: 1
Hydrophobicity: -82.86 Boman Index: -1340
Half-Life: 30 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 0
Instability Index: 6607.14 Extinction Coefficient cystines: 1490
Absorbance 280nm: 248.33

Literature

  • PubMed ID:  1686933
  • Title:  Identification of RFamide neuropeptides in the medicinal leech.